The Arizona Wildcats open the Big 12’s 2025 football schedule with a bye before visiting conference runner-up Iowa State on Sept. 27.

The Wildcats will get their first Big 12 crack at Iowa State, which lost the Big 12 title game in 2024 to ASU.

Arizona’s slate includes projected top 25 programs Arizona State, BYU and Iowa State. The Territorial Cup matchup will take place in Tempe this year on either Friday, Nov. 28, or Saturday, Nov. 29, after the Sun Devils defeated the Wildcats 49-7 last season in Tucson.

Arizona will miss Utah, Oklahoma State, Kansas, West Virginia and UCF. It will take on Kansas State in nonconference play, as the matchup was scheduled before the two programs became conference foes.

Ladies and gentlemen: the 2025 Big 12 Football Schedule 🏈🗓️ pic.twitter.com/kzjNGAFoKQ

— Big 12 Conference (@Big12Conference) February 4, 2025

Head coach Brent Brennan is in his second year leading the program and has made notable changes to his staff after a disappointing 4-8 campaign.

Seth Doege takes over as the offensive play-caller, and Danny Gonzales has shifted from special teams to defensive coordinator.

One area of continuity will be at quarterback with Noah Fifita returning for a third season.

Here is the Arizona football schedule for 2025:

Arizona Wildcats football 2025 schedule – Early Big 12 slate released

Nonconference schedule

Aug. 30: vs. Hawai’i

Sept. 6: vs. Weber State

Sept. 13: vs. Kansas State (scheduled before Arizona joined the Big 12)

Big 12 conference schedule 

Sept. 20: Bye

Sept. 27: at Iowa State

Oct. 4: vs. Oklahoma State

Oct. 11: vs. BYU

Oct. 18: at Houston

Oct. 25: Bye

Nov. 1: at Colorado

Nov. 8: vs. Kansas

Nov. 15: at Cincinnati

Nov. 22: vs. Baylor

Nov. 28 or 29: at Arizona State

Follow @alexjweiner